Title :
Continuous delivery of ions or drugs into single cells by a diffusional microburet
Author :
Yi, Chen ; Saidel, Gerald M. ; Gratzl, Miklos
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
The diffusional microburet (DMB) is a pulled glass capillary with a diffusion membrane at its tip. It is a useful tool to analyze ultramicro chemical samples and to study intracellular activities in single cells. In this work, a numerical simulation of a complete transport model for the DMB/cell interaction is obtained. A simplified analytical solution is also derived by assuming a uniform intracellular reagent/drug distribution and a quasi-steady state diffusion in the DMB. The simulation results compare well with the simplified analytical solution. More complicated cellular membrane transports are also discussed
Keywords :
biodiffusion; biomedical equipment; biomembrane transport; ions; patient treatment; physiological models; cellular membrane transports; continuous drugs delivery; continuous ions delivery; diffusion membrane; diffusional microburet; intracellular activities; numerical simulation; pulled glass capillary; quasisteady state diffusion; simplified analytical solution; ultramicro chemical samples; uniform intracellular reagent/drug distribution; Biological system modeling; Biomembranes; Cells (biology); Chemical analysis; Difference equations; Digital multimedia broadcasting; Drugs; Extracellular; Geometry; Numerical simulation;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415179
