Heterogeneity of SPECT bull´s-eyes in normal dogs: comparison of attenuation compensation algorithms

Author

DiBella, E.V.R. ; Eisner, R.L. ; Schmarkey, L.S. ; Barclay, A.B. ; Patterson, R.E. ; Nowak, D.J. ; Lalush, D.S. ; Tsui, B.M.W.

Author_Institution

Dept. of Electr. Eng., Georgia Inst. of Technol., Atlanta, GA, USA

Volume

4

fYear

1994

fDate

30 Oct-5 Nov 1994

Firstpage

1725

Abstract

In normal dogs, SPECT Tc-99m Sestamibi (MIBI) Tl-201 myocardial perfusion images reconstructed with filtered backprojection (FBP) show a large decrease of counts in the septal wall (S) compared to the lateral wall (L). We evaluated the iterative method of Chang at 0 and 1 iterations (Chang0 and Chang1), and the Maximum Likelihood-Expectation Maximization with attenuation compensation (ML-EM-ATN) algorithm on data acquired from 5 normal dogs and from simulated projection data using a homogeneous count-density model of a normal canine myocardium in the attenuation field measured in one dog. Mean counts in the S and L regions were calculated from maximum-count circumferential profile arrays. Our results demonstrate that ML-EM-ATN and Chang1 result in improved uniformity, as measured by the S/L ratio

Keywords

cardiology; image reconstruction; iterative methods; maximum likelihood estimation; medical image processing; single photon emission computed tomography; ²⁰¹Tl; ^99mTc; Maximum Likelihood-Expectation Maximization; SPECT Tc-99m Sestamibi; SPECT bull´s-eyes; Tc; Tl; Tl-201 myocardial perfusion images; attenuation compensation algorithms; filtered backprojection; heterogeneity; homogeneous count-density model; improved uniformity; iterative method; lateral wall; maximum-count circumferential profile arrays; normal canine myocardium; normal dogs; septal wall; simulated projection data; Animals; Attenuation; Biomedical imaging; Biomedical measurements; Computer simulation; Dogs; Image reconstruction; Iterative algorithms; Iterative methods; Myocardium;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium and Medical Imaging Conference, 1994., 1994 IEEE Conference Record

Conference_Location

Norfolk, VA

Print_ISBN

0-7803-2544-3

Type

conf

DOI

10.1109/NSSMIC.1994.474731

Filename

474731