Radiation effects in malignancy: a study using laser Doppler flowmetry

Author

Khan, M.M. ; Hussain, Muhammad Awais

fYear

1994

fDate

1994

Firstpage

956

Abstract

The work reported here used the microcirculatory approach for assessing radiation damage to the microvasculature. Head and neck cancer was selected for the in-vivo microcirculatory studies. Blood perfusion was recorded on the skin overlying the tumour as well as inside the tumour, using a noninvasive laser Doppler perfusion monitor. The perfusion of the skin over the tumour was found to be increased after radiation while inside the tumour perfusion was drastically decreased. It is proposed that a pre- and post-radiation microcirculation study is of great help for a radiation oncologist to design improved treatment modalities

Keywords

Doppler measurement; biological effects of ionising radiation; blood flow measurement; haemorheology; laser applications in medicine; radiation therapy; skin; blood perfusion; head/neck cancer; improved treatment modalities design; laser Doppler flowmetry; malignancy radiation effects; microcirculatory approach; microvasculature; radiation damage assessment; radiotherapy patients; skin perfusion; tumour perfusion; Acceleration; Biomedical applications of radiation; Cancer; Diseases; Magnetic heads; Neck; Patient monitoring; Radiation effects; Skin; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415231

Filename

415231