Title :
Adaptation of a minimal four-state cell model for reproducing atrial excitation properties
Author :
Weber, FM ; Lurz, S. ; Keller, DUJ ; Weiss, DL ; Seemann, G. ; Lorenz, C. ; Dössel, O.
Author_Institution :
Univ. Karlsruhe (TH), Karlsruhe
Abstract :
Simulation of cardiac excitation is often a trade-off between accuracy and speed. A promising minimal, time-efficient cell model with four state variables has recently been presented together with parametrizations for ventricular cell behaviour. In this work, we adapt the model parameters to reproduce atrial excitation properties as given by the Courtemanche model. The action potential shape is considered as well as the restitution of action potential duration and conduction velocity. Simulation times in a single cell and a tissue patch are compared between the two models. We further present the simulation of a sinus beat on the atria in a realistic 3D geometry using the fitted minimal model in a monodomain simulation.
Keywords :
biological tissues; cardiology; cellular biophysics; Courtemanche model; atria; atrial excitation; conduction velocity; minimal four-state cell model; realistic 3D geometry; sinus beat; tissue patch; Automata; Current density; Equations; Europe; Frequency; Geometry; Mathematical model; Shape control; Solid modeling; Voltage;
Conference_Titel :
Computers in Cardiology, 2008
Conference_Location :
Bologna
Print_ISBN :
978-1-4244-3706-1
DOI :
10.1109/CIC.2008.4748977