Title :
A low-noise miniaturized patch-clamp amplifier
Author :
Weerakoon, Pujitha ; Klemic, Kate ; Sigworth, Fred J. ; Culurciello, Eugenio
Author_Institution :
Yale Univ., New Haven
Abstract :
We present measurement results from a low-noise miniaturized patch-clamp amplifier with electrode compensation. The patch clamp amplifier has less than 4 pA of rms noise at a 10 kHz bandwidth and is capable of accurately measuring nano-Amperes of current. The device measurements shown here show that the integrated amplifier can be used for the design of high-density patch-clamp arrays.
Keywords :
amplifiers; bioelectric phenomena; biomedical electrodes; biomembrane transport; cell currents; electrode compensation; electrophysiologists; high-density patch-clamp arrays; ion channels; low-noise miniaturized patch-clamp amplifier; Bandwidth; Biomembranes; Clamps; Current measurement; Electrodes; Low-noise amplifiers; Principal component analysis; Throughput; Universal Serial Bus; Voltage;
Conference_Titel :
Life Science Systems and Applications Workshop, 2007. LISA 2007. IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4244-1813-8
Electronic_ISBN :
978-1-4244-1813-8
DOI :
10.1109/LSSA.2007.4400910
