• DocumentCode
    2356775
  • Title

    Identification of a pharmacophore on H1 histamine receptor antagonists: a molecular modeling study

  • Author

    Wokhlu, N. ; Yadav, J. ; Ritter, A. ; Kristol, D. ; Laxminarayan, Srinivas

  • Author_Institution
    Dept. of Biomed. Eng., New Jersey Inst. of Technol., Newark, NJ, USA
  • fYear
    1995
  • fDate
    15-18 Feb 1995
  • Firstpage
    26024
  • Lastpage
    26390
  • Abstract
    A systematic conformational search was performed on a set of H1 histamine receptor antagonists in an effort to define a pharmacophore. This study suggests that the H1 receptor may bind antihistamines with two acidic moieties located between 4.97A and 6.15A from one another. Disulfide bond formation is also possible for this class of antihistamines. This, however, would not explain reversible binding unless a thioesterase is involved
  • Keywords
    biology computing; bonds (chemical); chemistry computing; molecular biophysics; molecular configurations; organic compounds; H1 histamine receptor antagonists; acidic moieties; antihistamines; conformational search; disulfide bond formation; identification; mequitazine; methdilazine; molecular modeling; molecular recognition; pharmacophore; promethazine; protocol; reversible binding; thioesterase; trimeprazine; Biomedical computing; Biomedical engineering; Bonding; Chemical technology; Dentistry; Hardware; Nitrogen; Physiology; Protocols; Visualization;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 1995 and 14th Conference of the Biomedical Engineering Society of India. An International Meeting, Proceedings of the First Regional Conference., IEEE
  • Conference_Location
    New Delhi
  • Print_ISBN
    0-7803-2711-X
  • Type

    conf

  • DOI
    10.1109/RCEMBS.1995.533034
  • Filename
    533034
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2356775