Title :
Circuit model of neuronal spatial-temporal processing
Author :
Levine, Michael D.
Author_Institution :
Naval Res. Lab., Washington, DC, USA
Abstract :
A circuit model for the membrane of the input region of a neuron is developed for SPICE simulation. The model incorporates multiple synaptic inputs, which arise from the spatial distribution of transmitter-gated ion channels in the postsynaptic membrane. The activation of groups of ion channels is simulated in a temporally distributed sequence. The circuit provides a plausible representation of spatial and temporal processing in an individual neuron and thereby can serve as a model for developing a sophisticated processing element in a biological neural network
Keywords :
SPICE; bioelectric phenomena; biomembrane transport; cellular biophysics; neurophysiology; physiological models; SPICE simulation; biological neural network; circuit model; ion channels groups activation; neuron input region; neuronal spatial-temporal processing; postsynaptic membrane; sophisticated processing element; temporally distributed sequence; transmitter-gated ion channels spatial distribution; Biological system modeling; Biomembranes; Capacitance; Circuit simulation; FETs; MOSFET circuits; Neurons; Neurotransmitters; SPICE; Threshold voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415266
