Title :
Cardiac arrhythmias induced by an electrical stimulation at a cellular level
Author :
Jacquir, S. ; Binczak, S. ; Vandroux, D. ; Laurent, G. ; Athias, P. ; Bilbault, Jm
Author_Institution :
Lab. LE2I UMR CNRS 5158, Univ. of Burgundy, Dijon
Abstract :
To provide insights into the impulse propagation between cardiac myocytes, we performed studies of excitation spread with cellular resolution in confluent monolayers of cultured cardiomyocytes (CM). Multisite field potentials have been recorded using microelectrode arrays (MEA) technology in a basal condition and in proarrhythmic conditions induced by a high frequency electrical stimulation. The in vitro observation of spiral waves opens a new way to test the anti-arrhythmic drugs or strategies at cellular level.
Keywords :
bioelectric phenomena; biomedical electrodes; cardiology; cellular transport; basal condition; cardiac myocyte impulse propagation; cardiomyocyte confluent monolayers; cellular level electrical stimulation; electrical stimulation induced cardiac arrhythmia; excitation spread; high frequency electrical stimulation; microelectrode arrays; multisite field potentials; proarrhythmic conditions; spiral waves; Biological materials; Cardiology; Electrical stimulation; Fibrillation; Frequency; Hospitals; Microelectrodes; Pediatrics; Rhythm; Spirals;
Conference_Titel :
Computers in Cardiology, 2008
Conference_Location :
Bologna
Print_ISBN :
978-1-4244-3706-1
DOI :
10.1109/CIC.2008.4749119