Title :
Neural estimation of kinetic rate constants from dynamic PET-scans
Author :
Fog, Torben ; Nielsen, Lars Hupfeldt ; Hansen, Lars Kai ; Holm, Soren ; Law, Ian ; Svarer, Claus ; Paulson, Olaf
Author_Institution :
Electron. Inst., Tech. Univ. Denmark, Lyngby, Denmark
Abstract :
A feedforward neural net is trained to invert a simple three compartment model describing the tracer kinetics involved in the metabolism of [18F]fluorodeoxyglucose in the human brain. The network can estimate rate constants from positron emission tomography sequences and is about 50 times faster than direct fitting of rate constants using the parametrized transients of the compartment model
Keywords :
brain; feedforward neural nets; medical image processing; positron emission tomography; [18F]fluorodeoxyglucose; dynamic PET-scans; feedforward neural net; human brain; kinetic rate constants; metaboli; neural estimation; positron emission tomography sequences; three compartment model; tracer kinetics; Biochemistry; Biological neural networks; Blood; Brain modeling; Feeds; Hospitals; Kinetic theory; Nervous system; Positron emission tomography; Sugar;
Conference_Titel :
Neural Networks for Signal Processing [1994] IV. Proceedings of the 1994 IEEE Workshop
Conference_Location :
Ermioni
Print_ISBN :
0-7803-2026-3
DOI :
10.1109/NNSP.1994.366004