Partial volume correction of small animal PET cardiac dynamic images using iterative reconstruction: effects on glucose metabolic rate measurement

Author

D´Ambrosio, D. ; Fiacchi, G. ; Cilibrizzi, P. ; Lamberti, Claudio ; Baldazzi, G. ; Boschi, S. ; Franchi, R. ; Marengo, M. ; Spinelli, A.E.

Author_Institution

Scuola di Specializzazione in Fis. Sanitaria, Univ.´´ di Bologna, Bologna

fYear

2008

fDate

14-17 Sept. 2008

Firstpage

1093

Lastpage

1096

Abstract

Small animal positron emission tomography (PET) image quantitation is severely affected by partial volume effect (PVE) caused by the spatial resolution of PET tomographs. The aim of this work was to reduce the PVE using a modified iterative expectation maximization (EM) reconstruction algorithm. The goal of the method was to increase the accuracy of tracer concentration values in order to obtain an in vivo better estimate of physiological parameters. The performance of the proposed correction method was evaluated by calculating left ventricle and myocardium mean value using simulated cardiac fluorodeoxyglucose (FDG) dynamic images.

Keywords

biomedical measurement; cardiovascular system; expectation-maximisation algorithm; image reconstruction; image resolution; medical image processing; muscle; organic compounds; positron emission tomography; PET cardiac dynamic image; cardiac fluorodeoxyglucose; glucose metabolic rate measurement; image quantitation; iterative expectation maximization; iterative reconstruction; myocardium; partial volume effect; positron emission tomography; spatial resolution; tracer concentration value; Animals; Image reconstruction; In vivo; Myocardium; Parameter estimation; Positron emission tomography; Reconstruction algorithms; Spatial resolution; Sugar; Volume measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 2008

Conference_Location

Bologna

ISSN

0276-6547

Print_ISBN

978-1-4244-3706-1

Type

conf

DOI

10.1109/CIC.2008.4749236

Filename

4749236