An autoregulated pulsed-DC mode iontophoretic transdermal system

Author

Carley, C. ; Wolpert, S. ; Li, J.K.-J.

Author_Institution

Cardiovascular Res. Lab., Rutgers Univ., Piscataway, NJ, USA

fYear

1989

fDate

27-28 Mar 1989

Firstpage

51

Lastpage

52

Abstract

An autoregulated pulsed-DC iontophoretic device with slow turn-on current has been developed. A specialized high-frequency pulse with a duty cycle of 50% or less is used which will reduce skin irritation due to polarization effects. To avoid patient discomfort, current delivery is increased gradually over a two-minute period to allow the skin to adapt to the applied current level. The rate of drug delivery is regulated by controlling the energy of the delivered pulse. For antihypertensive-drug administration, the device measures the arterial pressure and continually readjusts delivery rates to keep it close to a desired target value

Keywords

bioelectric phenomena; electrophoresis; patient treatment; skin; antihypertensive-drug administration; arterial pressure; autoregulated pulsed-DC mode iontophoretic transdermal system; drug delivery rate; polarization effects; skin irritation effects; Cardiology; Circuit synthesis; Drug delivery; Electrodes; Frequency; Patient monitoring; Polarization; Pulse generation; Skin; Space vector pulse width modulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1989., Proceedings of the 1989 Fifteenth Annual Northeast

Conference_Location

Boston, MA

Type

conf

DOI

10.1109/NEBC.1989.36693

Filename

36693