Submicron contrast agents for the detection and localization of at risk lymph nodes

Author

Patel, Divia ; Dayton, Paul ; Gut, Jana ; Wisner, Erik ; Ferrara, Kathy

Author_Institution

Dept. of Biomed. Eng., California Univ., Davis, CA, USA

Volume

2

fYear

2001

fDate

2001

Firstpage

1717

Abstract

Ultrasound contrast agents can be readily administered to facilitate detection and localization of lymph nodes at risk for regional metastasis. The agent under observation is a sub-micron, gas-filled, double-walled microsphere that ruptures when exposed to ultrasound energy at megaHertz frequencies. Optically, we observe expansion of these microbubbles over an order of magnitude in radius. These results are supported with simulations from a modified Rayleigh-Plesset model

Keywords

biomedical ultrasonics; bubbles; cancer; US contrast agents; acoustic pressure; at risk lymph nodes detection; at risk lymph nodes localisation; center frequency; double-walled microsphere; gas-filled microsphere; microbubble disruption; microbubble expansion; modified Rayleigh-Plesset model; pulse length; regional metastasis; sentinel nodes; submicron contrast agents; ultrasound contrast agents; Acoustic pulses; Acoustic transducers; Biomedical optical imaging; Biomedical transducers; Breast cancer; Frequency; High speed optical techniques; Lymph nodes; Metastasis; Ultrasonic imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2001 IEEE

Conference_Location

Atlanta, GA

Print_ISBN

0-7803-7177-1

Type

conf

DOI

10.1109/ULTSYM.2001.992052

Filename

992052