DocumentCode
2372110
Title
Design and fabrication of a biomedical Lab-on-Chip system for SNP detection in DNA
Author
op de Beeck, M. ; De Malsche, W. ; Hiraoka, M. ; Fiorini, P. ; Zhang, L. ; op de Beeck, J. ; Majeed, B. ; Tanaka, H. ; Tezcan, D. Sabuncuoglu ; Desmet, G. ; Ueda, D. ; Van Hoof, C. ; Yamashita, I.
Author_Institution
imec, Leuven, Belgium
fYear
2010
fDate
6-8 Dec. 2010
Abstract
A Lab-on-Chip system is proposed, capable of SNP (Single Nucleotide Polymorphism) detection in DNA. One of the core components is an advanced filter consisting of an ordered array of Si micro-pillars enabling fast and effective separation of 5 DNA segments with different length using chromatographic techniques. Also a dedicated micro-pump is fabricated based on conductive polymer actuation, generating the required high pressure to sustain the fluid flow through the total system. For the detector, a known detector principle is applied, but pronounced miniaturization is carried out in order to make a small and portable system.
Keywords
DNA; chromatography; lab-on-a-chip; DNA; SNP detection; biomedical lab-on-chip system; chromatographic techniques; conductive polymer actuation; single nucleotide polymorphism detection;
fLanguage
English
Publisher
ieee
Conference_Titel
Electron Devices Meeting (IEDM), 2010 IEEE International
Conference_Location
San Francisco, CA
ISSN
0163-1918
Print_ISBN
978-1-4424-7418-5
Electronic_ISBN
0163-1918
Type
conf
DOI
10.1109/IEDM.2010.5703486
Filename
5703486
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