Title :
Design and fabrication of a biomedical Lab-on-Chip system for SNP detection in DNA
Author :
op de Beeck, M. ; De Malsche, W. ; Hiraoka, M. ; Fiorini, P. ; Zhang, L. ; op de Beeck, J. ; Majeed, B. ; Tanaka, H. ; Tezcan, D. Sabuncuoglu ; Desmet, G. ; Ueda, D. ; Van Hoof, C. ; Yamashita, I.
Author_Institution :
imec, Leuven, Belgium
Abstract :
A Lab-on-Chip system is proposed, capable of SNP (Single Nucleotide Polymorphism) detection in DNA. One of the core components is an advanced filter consisting of an ordered array of Si micro-pillars enabling fast and effective separation of 5 DNA segments with different length using chromatographic techniques. Also a dedicated micro-pump is fabricated based on conductive polymer actuation, generating the required high pressure to sustain the fluid flow through the total system. For the detector, a known detector principle is applied, but pronounced miniaturization is carried out in order to make a small and portable system.
Keywords :
DNA; chromatography; lab-on-a-chip; DNA; SNP detection; biomedical lab-on-chip system; chromatographic techniques; conductive polymer actuation; single nucleotide polymorphism detection;
Conference_Titel :
Electron Devices Meeting (IEDM), 2010 IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4424-7418-5
Electronic_ISBN :
0163-1918
DOI :
10.1109/IEDM.2010.5703486
