Finite element stress analysis of stenotic blood vessels

Author

MacWilliams, B.A. ; Savilonis, B.J. ; Hoffman, A.H.

Author_Institution

Dept. of Mech. Eng., Worcester Polytech. Inst., MA, USA

fYear

1989

fDate

27-28 Mar 1989

Firstpage

141

Lastpage

142

Abstract

Flow and lipid deposition in stenoses produced in rat aortas has been investigated by applying a U-shaped clip to reduce the cross-sectional area. Placing the clip on the exterior wall not only alter the flow through the vessel but also introduces stresses and strains within the vessel wall. A finite-element model of the deformed vessel wall has been developed. Results from the model were correlated with the distribution of cell shapes and lipid deposition obtained in animal experiments. The occurrence of polygonal (rounded) cells was strongly correlated with regions of elevated longitudinal stress

Keywords

blood; cellular biophysics; finite element analysis; haemodynamics; physiological models; stress analysis; U-shaped clip; cellular biophysics; cross-sectional area; deformed vessel wall; distribution of cell shapes; elevated longitudinal stress; finite-element model; lipid deposition; polygonal cell; rat aortas; rounded cell; stenotic blood vessels; stress analysis; Animals; Arteries; Blood vessels; Capacitive sensors; Finite element methods; Lipidomics; Morphology; Rats; Shape; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1989., Proceedings of the 1989 Fifteenth Annual Northeast

Conference_Location

Boston, MA

Type

conf

DOI

10.1109/NEBC.1989.36740

Filename

36740