Title :
Conceptual design of an RFQ accelerator-based neutron source for boron neutron-capture therapy
Author :
Wangler, T.P. ; Stovall, J.E. ; Bhatia, T.S. ; Wang, C.K. ; Blue, T.E. ; Gahbauer, R.A.
Author_Institution :
Los Alamos Nat. Lab., NM, USA
Abstract :
A conceptual design of a low-energy neutron generator for treatment of brain tumors by boron neutron capture therapy (BNCT) is presented. The concept is based on a 2.5-MeV proton beam from a radio-frequency quadrupole (RFQ) linac, and the neutrons are produced by the 7Li(p,n)7Be reaction. A liquid lithium target and modulator assembly are designed to provide a high flux of epithermal neutrons. The patient is administered a tumor-specific 10B-enriched compound and is irradiated by the neutrons to create a highly located dose from the reaction 10B(n,α) 7Li. An RFQ accelerator-based neutron source for BNCT is compact, which makes it practical to site the facility within a hospital
Keywords :
linear accelerators; neutron sources; radiation therapy; 10B(N,alpha); 7Li(p,n)7Be; B neutron capture therapy; RFQ accelerator-based neutron source; brain tumors; epithermal neutrons; linac; liquid Li target; low-energy neutron generator; radio-frequency quadrupole; tumor-specific 10B-enriched compound; Acceleration; Boron; Linear particle accelerator; Lithium; Medical treatment; Neoplasms; Neutrons; Particle beams; Proton accelerators; Radio frequency;
Conference_Titel :
Particle Accelerator Conference, 1989. Accelerator Science and Technology., Proceedings of the 1989 IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/PAC.1989.73220
