Alterative treatment of intractable epilepsy with focal brain cooling - A review of our past studies -

Author

Fujii, Masami ; Inoue, Takao ; He, Yeting ; Maruta, Yuichi ; Imoto, Hirochika ; Koizumi, Hiroyasu ; Nomura, Sadahiro ; Suzuki, Michiyasu ; Tokiwa, Tatsuji ; Ishizuka, Satoshi ; Yamakawa, Takeshi ; Yamakawa, Toshitaka

Author_Institution

Grad. Sch. of Med., Dept. of Neurosurg., Yamaguchi Univ., Ube, Japan

fYear

2011

fDate

9-12 Oct. 2011

Firstpage

681

Lastpage

685

Abstract

Focal cooling of the brain has the potential to terminate epileptic discharges. Therefore, in the present report, we review our past studies and discuss the future perspectives of brain cooling as a potential therapy for intractable epilepsy. The experiments were performed on Sprague-Dawley rats under halothane anesthesia. After craniotomy, the cooling device (Peltier chip) was placed on the cortical surface or inserted in the hippocampus. Kainic acid was then injected into either the cortex or hippocampus to provoke epileptiform discharges (EDs). Cortical cooling was also applied in patients with intractable epilepsy. The EDs decreased during either cortical or hippocampal cooling (20-25°C) in rats. The EDs diminished, and neurotransmitters, such as glutamate, were observed to decrease during cooling in epileptic patients. Both the effectiveness and safety of focal cooling for intractable epilepsy were demonstrated. Based on these data, developments of implantable focal cooling device have been promoted.

Keywords

brain; cooling; patient treatment; prosthetics; Peltier chip; Sprague-Dawley rats; cooling device; cortical cooling; craniotomy; epileptic discharges; epileptiform discharges; focal brain cooling; focal cooling; glutamate; halothane anesthesia; intractable epilepsy; kainic acid; neurotransmitters; Epilepsy; Heat sinks; Hippocampus; Neurosurgery; Rats; focal brain cooling; implantable device; seizure;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems, Man, and Cybernetics (SMC), 2011 IEEE International Conference on

Conference_Location

Anchorage, AK

ISSN

1062-922X

Print_ISBN

978-1-4577-0652-3

Type

conf

DOI

10.1109/ICSMC.2011.6083719

Filename

6083719