The effect of focal brain cooling on epileptic discharges in rats: Frequency analysis of electroencephalography

Author

Kida, Hiroyuki ; Fujii, Masami ; Inoue, Takao ; He, Yeting ; Maruta, Yuichi ; Nomura, Sadahiro ; Taniguchi, Kazuhiro ; Ichikawa, Takuya ; Saito, Takashi ; Suzuki, Michiyasu ; Yamakawa, Takeshi

Author_Institution

Dept. of Neurosci. & Neurosurg., & Appl. Med. Eng. Sci., Med. Yamaguchi Univ., Ube, Japan

fYear

2011

fDate

9-12 Oct. 2011

Firstpage

686

Lastpage

690

Abstract

To investigate the effect of focal brain cooling on seizure, spectral analysis of electroencephalography (EEG) was performed in anesthetized rats intracortically injected with penicillin G potassium. Penicillin G induced epileptic discharges (EDs) and increased high frequency EEG bands. Use of a cooling device suppressed EDs with an effect that depended on the brain temperature. Fast Fourier Transform (FFT) analysis indicated that cooling to 25°C terminated the higher frequency EEG activity in Beta bands, cooling to 20°C suppressed the power spectra for both Alpha and Beta waves, and cooling to 15°C completely suppressed all spectral bands. These results suggest that a focal cooling device can terminate EDs and suppress EEG frequency bands in a manner that is dependent on the brain temperature. These findings contribute to development of clinical treatment for patients with EDs.

Keywords

cooling; electroencephalography; fast Fourier transforms; medical signal processing; spectral analysis; EEG; FFT analysis; alpha wave; anesthetized rat; beta wave; brain temperature; clinical treatment; cooling device; electroencephalography; epileptic discharge; fast Fourier transform; focal brain cooling; frequency analysis; penicillin G potassium; power spectra; seizure; spectral analysis; temperature 20 C; temperature 25 C; Cooling; Discharges; Electroencephalography; Epilepsy; Performance evaluation; Rats; epilepsy; focal cooling; frequency; penicillin G; rat;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems, Man, and Cybernetics (SMC), 2011 IEEE International Conference on

Conference_Location

Anchorage, AK

ISSN

1062-922X

Print_ISBN

978-1-4577-0652-3

Type

conf

DOI

10.1109/ICSMC.2011.6083720

Filename

6083720