Title :
Enhancement of the immune response to chronic myeloid leukaemia via controlled treatment scheduling
Author :
Chang, H. ; Astolfi, A.
Author_Institution :
Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK
Abstract :
We study the differential equations describing the chronic myeloid leukaemia. We propose a novel drug scheduling method to enhance the T-cell mediated immune response. The control strategy relies on the understanding of the immune boosting mechanism. The feasibility of the strategy is illustrated via simulations.
Keywords :
blood; cancer; cellular biophysics; differential equations; drugs; medical control systems; patient treatment; tumours; T-cell mediated immune response; chronic myeloid leukaemia; controlled treatment scheduling; differential equations; drug scheduling method; immune boosting mechanism; immune response; Algorithms; Antineoplastic Agents; Cancer Vaccines; Computational Biology; Computer Simulation; Drug Administration Schedule; Drug Therapy; Humans; Immune System; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocyte Activation; Models, Statistical; T-Lymphocytes; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5332648
