DocumentCode :
2379911
Title :
Toward functional neurobehavioral assessment of mood and anxiety
Author :
Lindsey, LaRaun ; King-Casas, Brooks ; Brovko, Julie ; Chiu, Pearl H.
Author_Institution :
Dept. of Neurosci., Baylor Coll. Med., Houston, TX, USA
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
5393
Lastpage :
5396
Abstract :
Mood and anxiety disorders confer marked personal and fiscal cost. Current therapeutic efforts show only moderate efficacy, and little is known about the characteristics of those who respond to specific treatment regimens. The lack of objective descriptors of symptom severity and reliable predictors of illness outcome contributes to limited diagnostic and treatment success. Here, we have begun to develop a normative neurobehavioral database of responses to affective stimuli by combining functional magnetic resonance imaging (fMRI), with comprehensive behavioral assessment and quantitative analyses of neural responses to standard emotional cues. These data reveal robust and distinct neural patterns between two groups with similar low self-reported depression and anxiety, and one group with high depression and anxiety scores. This and related strategies may be used to identify covert phenotypes associated with psychiatric illness and resilience.
Keywords :
biomedical MRI; neurophysiology; patient diagnosis; patient treatment; anxiety disorders; depression; functional magnetic resonance imaging; functional neurobehavioral assessment; illness outcome predictors; mood disorders; neural patterns; neurobehavioral database; psychiatric illness; resilience; symptom severity; Adult; Affect; Anxiety; Behavior; Cluster Analysis; Depression; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5332809
Filename :
5332809
Link To Document :
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