Transcriptional regulation of drug target proteins from cancer related disease network

Traditionally, most researches in development of new drug target focus on relationship between a target protein and a related compound by experimental or computational approaches. In addition to the translational level, it is useful tool control disease at the transcriptional level, if we identify transcription factors that regulate expression of target proteins. We introduce new methodology that derives transcription factors from upstream sequences of sixty target proteins that previously obtained. We analyze correlation among disease, transcription factor, and target protein, characterize the transcription factor binding site, and simulate inhibitor of the DNA and transcription factor. These results provide insight that controls disease at the transcriptional level.