Title :
Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro
Author :
Kobayashi, Kozue ; Tanaka, Masumi ; Inaoka, Hidenori ; Nebuya, Satoru ; Kokubo, Kenichi ; Fukuoka, Yutaka ; Kobayashi, Hirosuke ; Noshiro, Makoto
Author_Institution :
Grad. Sch. of Med. Sci., Kitasato Univ., Sagamihara, Japan
Abstract :
The effects of cyclic stretch (within 30 min) on the expressions of early response genes in normal human pulmonary artery endothelial cells (HPAEC) were investigated using an in vitro stretch system. The investigated early response genes were early growth response gene 1 (Egr1), heat-shock protein 4 (Hspa4), PTGS4 (cox2) and the inflammatory cytokines interleukin (IL)-1, IL-6 and IL-8. The genes of Egr1 and PTGS2 were upregulated at early stages by cycle stretch.
Keywords :
biomechanics; blood vessels; cellular biophysics; genetics; molecular biophysics; Egr1; Hspa4; IL-1; IL-6; IL-8; PTGS4; cox2; cyclic stretch effects; early growth response gene 1; early response gene expressions; heat shock protein 4; human pulmonary artery endothelial cells; in vitro normal HPAEC; inflammatory cytokine interleukin; VALI; component; early response genes; excessive cyclic stretch;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location :
Hong, Kong
Print_ISBN :
978-1-4244-8303-7
Electronic_ISBN :
978-1-4244-8304-4
DOI :
10.1109/BIBMW.2010.5703944
