Title :
microDoR for HUMAN: A web server to predict mode of miRNA-mediated gene silencing
Author :
Cheng, Lei ; Zhou, Tao ; Guo, Xuejiang ; Song, Xiaofeng ; Zhang, Xiaobai ; Han, Ping ; Chen, Yi-Ping Phoebe ; Sha, Jiahao
Author_Institution :
Dept. of Biomed. Eng., Nanjing Univ. of Aeronaut. & Astronaut., Nanjing, China
Abstract :
microDoR Human is a web server tool based on machine learning algorithm to predict Human miRNA-mediated gene silencing: mRNA degradation or translational repression. For a miRNA-mRNA interaction, microDoR Human identifies whether the target mRNA is cleaved or translationally inhibite. microDoR Human is expected to serve as a useful tool for understanding of miRNA-mediated gene regulation. The microDoR Human 1.0 can be available in http://reprod.njmu.edu.cn/microdor /.
Keywords :
Web services; biology computing; cellular biophysics; genetics; molecular biophysics; organic compounds; HUMAN; cleaved mRNA; mRNA degradation; mRNA translational repression; machine learning algorithm; miRNA mediated gene regulation; miRNA mediated gene silencing mode prediction; miRNA-mRNA interaction; microDoR; translationally inhibited mRNA; web server; degradation; miRNA; translational repression;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on
Conference_Location :
Hong, Kong
Print_ISBN :
978-1-4244-8303-7
Electronic_ISBN :
978-1-4244-8304-4
DOI :
10.1109/BIBMW.2010.5703952
