Modifications to the Wilders-Jongma-van Ginneken model of pacemaker electrical activity

Author

Dokos, Socrates ; Celler, Branko ; Lovel, Nigel

Author_Institution

Sch. of Electr. Eng., New South Wales Univ., Kensington, NSW, Australia

fYear

1994

fDate

1994

Firstpage

1202

Abstract

The Wilders-Jongsma-van Ginneken single cell model of sinoatrial node electrical activity was found to be unsuitable for simulating autonomic modulation of sinoatrial node rhythm. The equations were modified by reducing the effects of the large sarcoplasmic reticulum calcium store, altering the kinetics of the L-type calcium current, and modifying the activation curve of the hyperpolarizing-activated current i_f. The resulting model was able to reproduce the chronotropic responses of cardiac period to sympathetic and parasympathetic stimulation

Keywords

cardiology; Ca; L-type calcium current; Wilders-Jongma-van Ginneken model; activation curve; autonomic modulation; cardiac period; chronotropic responses; hyperpolarizing-activated current; large sarcoplasmic reticulum calcium store; pacemaker electrical activity; parasympathetic stimulation; single cell model; sinoatrial node electrical activity; sinoatrial node rhythm; sympathetic stimulation; Australia; Biological system modeling; Biology; Biomembranes; Calcium; Equations; Kinetic theory; Laboratories; Pacemakers; Rhythm;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415393

Filename

415393