Title :
A configurable IC for wireless real-time in vivo monitoring of chemical and electrical neural activity
Author :
Roham, Masoud ; Blaha, Charles D. ; Garris, Paul A. ; Lee, Kendall H. ; Mohseni, Pedram
Author_Institution :
Electr. Eng. & Comput. Sci. Dept, Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm2 IC is fabricated using a 0.5-mum CMOS process and incorporates a 71-muW, 3rd-order, configurable, DeltaSigma modulator per channel, achieving an input-referred noise of 4.69 muVrms in 4-kHz BW and 94.1 pArms in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing, respectively. Brain extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been recorded wirelessly on multiple channels using 300-V/s fast-scan cyclic voltammetry in the anesthetized rat.
Keywords :
CMOS integrated circuits; biochemistry; bioelectric phenomena; biomedical electronics; biomedical measurement; delta-sigma modulation; medical signal processing; neurophysiology; voltammetry (chemical analysis); CMOS technology; DeltaSigma modulator; anesthetized rat; brain extracellular dopamine level; chemical neural activity; configurable IC; electrical neural activity; electrical stimulation; fast-scan voltammetric chemical neurosensing; input-referred noise; medial forebrain bundle; wireless real-time in vivo monitoring; Animals; Computer Communication Networks; Electronics; Electrophysiology; Equipment Design; Male; Microelectrodes; Models, Neurological; Monitoring, Ambulatory; Nerve Net; Rats; Telemetry; Time Factors; Transducers;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333089
