Title :
Methods to enhance laser speckle imaging of high-flow and low-flow vasculature
Author :
Choi, Bernard ; Ringold, Tyson L. ; Kim, Jeehyun
Author_Institution :
Depts. of Biomed. Eng. & Surg., Univ. of California, Irvine, CA, USA
Abstract :
The objective of this paper is to present two methods to extend the response range of laser speckle imaging (LSI). We report on the use of two methods (image exposure time control and magnetomotive actuation of exogenous contrast agents) to enhance characterization of high- and low-flow vasculature, respectively. With an exposure time of 10 and 0.01 ms, the linear response range extended to 10 and 280 mm/s, respectively. With application of an AC magnetic field to a solution of stagnant SPIO particles, an apparent increase of ~3times in speckle flow index was induced.
Keywords :
biomedical optical imaging; blood vessels; haemodynamics; image enhancement; laser applications in medicine; speckle; AC magnetic field; blood flow dynamics characterization; exogenous contrast agents; high-flow vasculature; image exposure time control; laser speckle image enhancement; linear response; low-flow vasculature; magnetomotive actuation; speckle flow index; stagnant SPIO particles; time 0.01 ms; time 10 ms; Algorithms; Blood Flow Velocity; Crystallization; Ferric Compounds; Humans; Image Interpretation, Computer-Assisted; Lasers; Magnetics; Metal Nanoparticles; Nanotechnology; Phantoms, Imaging; Regional Blood Flow; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333204
