Title :
Common median referencing for improved action potential detection with multielectrode arrays
Author :
Rolston, John D. ; Gross, Robert E. ; Potter, Steve M.
Author_Institution :
Dept. of Neurological Surg., Emory Univ. Sch. of Med., Atlanta, GA, USA
Abstract :
Referencing is frequently used to remove common-mode signals from multielectrode data, in both freely moving animals and in vitro preparations. For action potential (AP) detection, referencing by subtracting the common average signal has been shown to increase AP signal-to-noise ratio (SNR). This method fails, however, when large transients occur on individual electrodes, as occurs during electrical stimulation or with large APs during spontaneous recordings. To deal with these cases, we propose using the common median as a reference. The common median has an improved SNR for AP detection (leading to more isolated single units and more detected APs per unit) and, unlike common average referencing, does not generate spurious APs when processing large single-electrode transients.
Keywords :
bioelectric potentials; biomedical electrodes; brain; medical signal detection; medical signal processing; neurophysiology; AP detection; AP signal-to-noise ratio; SNR; action potential detection; common average signal subtraction; common median referencing; common-mode signal removal method; electrical stimulation; freely moving animals; in vitro preparations; multielectrode arrays; single-electrode transients; spontaneous recordings; Action Potentials; Animals; Electric Stimulation; Electrodes; Male; Rats; Rats, Sprague-Dawley;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333230