In vivo study of percutaneous absorption of lidocaine using electret in the rat

Author

Cui, L.L. ; Jiang, J. ; Song, C.R. ; Zhao, W.Q. ; Weiquan, D. ; Xia, Z.F.

Author_Institution

Dept. of Pharmacy, Second Mil. Med. Univ., Shanghai, China

fYear

2002

fDate

2002

Firstpage

419

Lastpage

421

Abstract

The present work was undertaken to study the effect of electret on transdermal drug delivery in vivo. The experiment was carried out in depilated abdominal rat skin using lidocaine hydrochloride as a model compound. Rats were divided into control and electret group. The electrets were applied on the drug in a vial and the blood samples were taken from jugular vein at predetermined time intervals. The concentration of lidocaine in plasma was measured by high proficiency liquid chromatograph (HPLC) after extraction. The plasma lidocaine concentration was significantly increased in electret group. The results suggested that electret could promote the permeability of drug by its effect on the structure of epidermis and blood flow change.

Keywords

bioelectric phenomena; chromatography; drug delivery systems; electrets; organic compounds; skin; blood flow; depilated abdominal rat skin; electret; epidermis structure; high proficiency liquid chromatography; in vivo transdermal drug delivery; lidocaine hydrochloride; percutaneous absorption; plasma concentration; Abdomen; Absorption; Blood; Drug delivery; Electrets; In vivo; Plasma measurements; Rats; Skin; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Electrets, 2002. ISE 11. Proceedings. 11th International Symposium on

Print_ISBN

0-7803-7560-2

Type

conf

DOI

10.1109/ISE.2002.1043031

Filename

1043031