Title :
CMOS Integrated DNA Microarray Based on GMR Sensors
Author :
Han, Shu-Jen ; Xu, Liang ; Yu, Heng ; Wilson, Robert J. ; White, Robert L. ; Pourmand, Nader ; Wang, Shan X.
Author_Institution :
Dept. of Mater. Sci. & Eng., Stanford Univ., CA
Abstract :
A high density GMR sensor array was integrated with a standard CMOS chip for DNA hybridization detection. Absorption of magnetic nanoparticles by the hybridized DNA alters the sensor resistance, and generated electrical signals are directly measured with the on-die circuitry. The proposed biochip can be applied to other bio-reaction detection, e.g. protein assay, through different surface modifications
Keywords :
CMOS integrated circuits; DNA; biosensors; giant magnetoresistance; magnetic particles; magnetic sensors; nanoparticles; CMOS chip; CMOS integrated DNA microarray; DNA hybridization detection; GMR sensor array; biochip; bioreaction detection; electrical signals; magnetic nanoparticles; protein assay; surface modifications; Absorption; Biosensors; DNA; Electric resistance; Hybrid power systems; Immune system; Magnetic sensors; Nanoparticles; Sensor arrays; Signal generators;
Conference_Titel :
Electron Devices Meeting, 2006. IEDM '06. International
Conference_Location :
San Francisco, CA
Print_ISBN :
1-4244-0438-X
Electronic_ISBN :
1-4244-0439-8
DOI :
10.1109/IEDM.2006.346887
