Exploring the Prospects for a Nanometer-scale Gene Chip

Author

Dimitrov, V. ; Aksimentiev, A. ; Schulten, K. ; Heng, J. ; Sorsch, T. ; Mansfield, W. ; Miner, J. ; Watson, G.P. ; Cirelli, R. ; Klemens, F. ; Bower, Jacob ; Ferry, E. ; Taylor, A. ; Kornblit, A. ; Dorvel, B. ; Zhao, Q. ; Timp, G.

Author_Institution

Univ. of Illinois, Urbana , IL

fYear

2006

fDate

11-13 Dec. 2006

Firstpage

1

Lastpage

4

Abstract

We are exploring the feasibility of sequencing a single molecule of DNA using a revolutionary type of silicon integrated circuit that incorporates an on-chip nanopore mechanism with a molecular trap. The essential component is a single, nanometer-diameter pore in a robust, nanometer-thick membrane formed from a metal oxide semiconductor (MOS) capacitor. To sequence the molecule, the voltage induced by the dipole moment associated with each base is measured using the electrodes on the capacitor as the DNA translocates through the pore

Keywords

DNA; MOS capacitors; biomedical engineering; elemental semiconductors; integrated circuit manufacture; integrated circuit measurement; nanotechnology; silicon; DNA; Si; metal oxide semiconductor capacitor; molecular trap; nanometer-diameter pore; nanometer-scale gene chip; on-chip nanopore mechanism; silicon integrated circuit; Biomembranes; DNA; Electrodes; Integrated circuit measurements; MOS capacitors; Nanoporous materials; Robustness; Sequences; Silicon; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices Meeting, 2006. IEDM '06. International

Conference_Location

San Francisco, CA

Print_ISBN

1-4244-0438-X

Electronic_ISBN

1-4244-0439-8

Type

conf

DOI

10.1109/IEDM.2006.346987

Filename

4154422