Title :
Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study
Author :
Zhang, Dandan ; Hathi, Manan ; Yang, Zeng-Jin ; Ding, Haiyan ; Koehler, Raymond ; Thakor, Nitish
Author_Institution :
Dept. of Biomed. Eng., Tsinghua Univ., Beijing, China
Abstract :
To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).
Keywords :
bioelectric phenomena; biological tissues; electroencephalography; neurophysiology; paediatrics; patient diagnosis; aEEG; amplitude-integrated electroencephalogram; brain injury; cerebral hypoxic ischemia; histological outcomes; neonatal intensive care unit; neonatal piglets; Animals; Animals, Newborn; Asphyxia Neonatorum; Biomedical Engineering; Brain Injuries; Disease Models, Animal; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Monitoring, Physiologic; Reproducibility of Results; Swine;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333439
