Effects of the electrical double layer and dispersive tissue properties in a volume conduction model of deep brain stimulation

Author

Grant, Peadar F ; Lowery, Madeleine M.

Author_Institution

Sch. of Electr., Electron. & Mech. Eng., Univ. Coll. Dublin, Dublin, Ireland

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

6497

Lastpage

6500

Abstract

The aim of this study was to investigate the interaction of the electrode-tissue interface and dispersive tissue properties on waveforms used for deep brain stimulation. A finite element model with a distributed impedance electrical double layer was developed. Bulk tissue capacitance and dispersion were found to alter the voltage waveform under constant current stimulation. When the electrode was surrounded by conductive saline or white matter tissue, the electrical double layer was dominant under voltage controlled stimulation. However, as encapsulation tissue resistivity was increased, to emulate chronic stimulation, the voltage waveform approached that observed during constant current stimulation and the influence of the frequency dependent material properties again became dominant.

Keywords

bioelectric phenomena; biological tissues; diseases; electrical resistivity; finite element analysis; neurophysiology; patient treatment; physiological models; bulk tissue capacitance; conductive saline; deep brain stimulation; dispersive tissue properties; distributed impedance layer; electrical double layer effects; electrode-tissue interface; encapsulation tissue resistivity; finite element model; frequency-dependent material properties; voltage controlled stimulation; voltage waveform; volume conduction model; white matter tissue; Action Potentials; Animals; Brain; Computer Simulation; Deep Brain Stimulation; Humans; Models, Neurological; Nerve Net; Neural Conduction; Therapy, Computer-Assisted;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5333592

Filename

5333592