DocumentCode :
2394715
Title :
Gender related differences in cerebral autoregulation in older healthy subjects
Author :
Deegan, Brian M. ; Sorond, Farzaneh A. ; Lipsitz, Lewis A. ; ÓLaighin, Gearóid ; Serrador, Jorge M.
Author_Institution :
Dept. of Electr. & Electron. Eng., NUI Galway, Galway, Ireland
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
2859
Lastpage :
2862
Abstract :
Cerebral autoregulation is an intrinsic mechanism of the cerebrovasculature that maintains cerebral blood flow relatively constant over a wide range of blood pressures. Recent studies have shown sex differences in cerebral autoregulation in adolescents and young adults. We evaluated cerebral auturegulation in 419 (186 male) subjects over the age of 70 recruited as part of the MOBILIZE Boston study. CO2 reactivity, transfer function gain and autoregulatory index (ARI) during sit to stand tests were assessed. Female subjects had significantly higher CO2 reactivity (p < 0.001) and vasomotor range (p<0.001) as well as ARI indices (p<0.001) and lower transfer function gain in the autoregulatory band (p=0.001), implying better cerebral autoregulation, than male subjects. The mechanisms of sex based differences in cerebral autoregulation remain unclear, but the results of this study highlight the need for future work to better understand these underlying autoregulatory differences.
Keywords :
biochemistry; blood vessels; brain; haemodynamics; CO2 reactivity; MOBILIZE Boston study; autoregulatory index; cerebral autoregulation; cerebral blood flow; cerebrovasculature; gender related differences; older healthy subjects; transfer function gain; vasomotor range; Aged; Blood Flow Velocity; Brain; Carbon Dioxide; Cerebrovascular Circulation; Electrocardiography; Female; Hemodynamics; Homeostasis; Humans; Male; Middle Cerebral Artery; Models, Cardiovascular; Sex Factors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5333604
Filename :
5333604
Link To Document :
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