Title :
Modulation of Instantaneous Synchrony During Seizures by Deep Brain Stimulation
Author :
Fine, A.S. ; Nicholls, David P. ; Mogul, David J.
Author_Institution :
Fine Dept. of Bioeng., Univ. of Illinois, Chicago, IL, USA
Abstract :
Epileptic seizures were experimentally induced in the CA3 region of rat hippocampus in vivo. Recordings of seizure activity were made in both hippocampi as well as anteromedial region of the thalamus in order to analyze the instantaneous activity for synchronous oscillators. A new method is introduced for detecting this synchrony which combines empirical mode decomposition, the Hilbert analytic signal method and eigenvalue decomposition. Effects of targeted deep brain stimulation on multi-site synchrony were assessed as a means to extinguish hypersynchrony during epileptic seizures.
Keywords :
eigenvalues and eigenfunctions; electroencephalography; medical signal processing; synchronisation; CA3 region; EEG; Hilbert analytic signal method; anteromedial region; deep brain stimulation; eigenvalue decomposition; empirical mode decomposition; epileptic seizures; hypersynchrony; instantaneous synchrony modulation; multi-site synchrony; rat hippocampus; synchronous oscillators; thalamus; Empirical Mode Decomposition; epilepsy; synchrony; Algorithms; Animals; Brain; Brain Mapping; Deep Brain Stimulation; Electrophysiology; Epilepsy; Hippocampus; Male; Models, Statistical; Oscillometry; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333714
