• DocumentCode
    2399003
  • Title

    Molding single DNA molecules in metals and sample preparation for electronic sequencing

  • Author

    Lund, John A. ; Parviz, Babak A.

  • Author_Institution
    Electr. Eng. Dept., Univ. of Washington, Seattle, WA, USA
  • fYear
    2009
  • fDate
    3-6 Sept. 2009
  • Firstpage
    2779
  • Lastpage
    2782
  • Abstract
    We demonstrate the molding of single DNA molecules in 8 nm thin platinum molds. The molded structures have an apparent depth of 1 nm under STM imaging, and closely follow the contours of the DNA molecules. We have confirmed the presence of the embedded molecules and have verified the ability of this technique to scale down to single molecules. Additionally, we have utilized this method to perform electron tunneling analysis on embedded DNA molecules.
  • Keywords
    DNA; biological techniques; molecular biophysics; moulding; platinum; scanning tunnelling microscopy; DNA molecule; DNA sequencing; Pt; STM imaging; depth 1 nm; electron tunneling analysis; electronic sequencing; molded structures; size 8 nm; thin platinum molds; Bacteriophage lambda; Carbon; DNA; Electric Conductivity; Electrochemistry; Electronics; Electrons; Metals; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Scanning Tunneling; Platinum; Reproducibility of Results;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
  • Conference_Location
    Minneapolis, MN
  • ISSN
    1557-170X
  • Print_ISBN
    978-1-4244-3296-7
  • Electronic_ISBN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/IEMBS.2009.5333862
  • Filename
    5333862