DocumentCode
2399003
Title
Molding single DNA molecules in metals and sample preparation for electronic sequencing
Author
Lund, John A. ; Parviz, Babak A.
Author_Institution
Electr. Eng. Dept., Univ. of Washington, Seattle, WA, USA
fYear
2009
fDate
3-6 Sept. 2009
Firstpage
2779
Lastpage
2782
Abstract
We demonstrate the molding of single DNA molecules in 8 nm thin platinum molds. The molded structures have an apparent depth of 1 nm under STM imaging, and closely follow the contours of the DNA molecules. We have confirmed the presence of the embedded molecules and have verified the ability of this technique to scale down to single molecules. Additionally, we have utilized this method to perform electron tunneling analysis on embedded DNA molecules.
Keywords
DNA; biological techniques; molecular biophysics; moulding; platinum; scanning tunnelling microscopy; DNA molecule; DNA sequencing; Pt; STM imaging; depth 1 nm; electron tunneling analysis; electronic sequencing; molded structures; size 8 nm; thin platinum molds; Bacteriophage lambda; Carbon; DNA; Electric Conductivity; Electrochemistry; Electronics; Electrons; Metals; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Scanning Tunneling; Platinum; Reproducibility of Results;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location
Minneapolis, MN
ISSN
1557-170X
Print_ISBN
978-1-4244-3296-7
Electronic_ISBN
1557-170X
Type
conf
DOI
10.1109/IEMBS.2009.5333862
Filename
5333862
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