A high voltage amplifier for use in medical applications of electroporation

Author

Gaynor, Paul ; Skipwith, Jonathan

Author_Institution

Dept. of Phys. & Electron. Eng., Waikato Univ., Hamilton, New Zealand

fYear

2002

fDate

2002

Firstpage

483

Lastpage

485

Abstract

The bio-physical effect known as electroporation or electropermeabilization is becoming more widely used in medical treatment, especially for chemotherapy and gene therapy. The conventional electrical apparatus used is based on DC voltage pulses which may not be optimal. Indications are that AC pulses may provide significant improvements. A high voltage linear amplifier design incorporating vacuum tube valves is presented that could facilitate AC pulse experimentation. Valves are used as they most readily suit the desired electrical specifications of an output voltage of 4kV_p, a bandwidth of 500 Hz-5 MHz, a voltage gain of 52 dB, and an output impedance of <100 Ω

Keywords

bioelectric phenomena; biological effects of fields; differential amplifiers; patient treatment; power amplifiers; pulse amplifiers; triodes; valves; 4 kV; 500 Hz to 5 MHz; 52 dB; AC pulse experimentation; chemotherapy; differential triode valve amplifier; electropermeabilization; electroporation; gene therapy; high electric field; high voltage linear amplifier; medical applications; medical treatment; output impedance; output voltage; vacuum tube valves; voltage gain; Bandwidth; Biomedical equipment; Electron tubes; Gain; Gene therapy; Medical services; Medical treatment; Pulse amplifiers; Valves; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronic Design, Test and Applications, 2002. Proceedings. The First IEEE International Workshop on

Conference_Location

Christchurch

Print_ISBN

0-7695-1453-7

Type

conf

DOI

10.1109/DELTA.2002.994679

Filename

994679