Regression-based analysis of synchronization in multichannel EEG in epilepsy

In this paper we assess a dependency measure for multivariate time series termed extrinsic-to-intrinsic-power-ratio (EIPR) using two different signal models. In a comparison with partial directed coherence (PDC) we show that both measures correctly identify imposed couplings, but that limitations of the PDC do not affect EIPR. Moreover, EIPR is successfully used for the localization of the seizure onset zone in ECoG recordings from two epilepsy patients, given the exact seizure onset time. The electrodes identified by the proposed method are in excellent accordance with the clinical findings.