Biological microdevice with fluidic acoustic streaming for measuring uric acid in human saliva

Author

Cardoso, V.F. ; Catarino, S.O. ; Martins, P. ; Rebouta, L. ; Lanceros-Mendéz, S. ; Minas, G.

Author_Institution

Dept. of Ind. Electron., Univ. of Minho, Guimaraes, Portugal

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

5879

Lastpage

5882

Abstract

The healthcare system requires new devices for a rapid monitoring of a patient in order to improve the diagnosis and treatment of various diseases. Accordingly, new biomedical devices are being developed. In this paper, a fully-integrated biological microdevice for uric acid analysis in human saliva is presented. It is based on optical spectrophotometric measurements and incorporates a mixture system based on acoustic streaming, that enhances the fluids reaction due to both heating and agitation generated by this effect. Acoustic streaming is provided by a piezoelectric beta-PVDF film deposited underneath the microfluidic die of the device. Further, it incorporates the electronics for the detection, readout, data processing and signal actuation. Experimental results proved that acoustic streaming based on this piezoelectric polymer is advantageous and reduces in 55% the time required to obtain the analysis results.

Keywords

acoustic streaming; bio-optics; bioMEMS; biomedical electronics; biomedical equipment; biomedical measurement; health care; microfluidics; patient monitoring; piezoelectric thin films; polymer films; spectrochemical analysis; spectrophotometry; biological microdevice; biomedical device; disease diagnosis; fluidic acoustic streaming; healthcare system; human saliva; microfluidic die; optical spectrophotometric measurement; patient monitoring; patient treatment; piezoelectric beta-PVDF film; piezoelectric polymer; uric acid; Acoustics; Biosensing Techniques; Equipment Design; Equipment Failure Analysis; Flow Injection Analysis; Humans; Micro-Electrical-Mechanical Systems; Microfluidics; Miniaturization; Reproducibility of Results; Saliva; Sensitivity and Specificity; Uric Acid;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5334449

Filename

5334449