Title :
Multi-objective evolutionary algorithms based Interpretable Fuzzy models for microarray gene expression data analysis
Author :
Wang, Zhenyu ; Palade, Vasile
Author_Institution :
Comput. Lab., Oxford Univ., Oxford, UK
Abstract :
We believe the great interpretability of fuzzy models allow fuzzy-based methods to play a very important role in Microarray gene expression data analysis, but the advantages offered by fuzzy-based techniques in this application have not yet been fully explored in the literature. In this paper, we construct Multi-Objective Evolutionary Algorithms based Interpretable Fuzzy (MOEAIF) models for microarray gene expression data analysis. Our novel fuzzy models can significantly decrease the model complexity, and automatically balance the accuracy and interpretability of the models. The experimental studies have shown that relatively simple and small fuzzy rule bases, with satisfactory classification performance, have been successful found for challenging microarray gene expression datasets.
Keywords :
bioinformatics; evolutionary computation; fuzzy systems; genetics; MOEAIF models; Multi-Objective Evolutionary Algorithms based Interpretable Fuzzy model; fuzzy rule bases; fuzzy-based method; interpretable fuzzy models; microarray gene expression data analysis; multiobjective evolutionary algorithms; Accuracy; Analytical models; Cancer; Computational modeling; Data models; Gene expression; Testing; Cancer gene expression data; evolutionary algorithms; feature selection; fuzzy rule-based systems; microarray data analysis; model interpretability; multi-objective optimisation;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-8306-8
Electronic_ISBN :
978-1-4244-8307-5
DOI :
10.1109/BIBM.2010.5706582