Title :
A comparative study of two matrix factorization methods applied to the classification of gene expression data
Author :
Nikulin, Vladimir ; Huang, Tian-Hsiang ; McLachlan, Geoffrey J.
Author_Institution :
Dept. of Math., Univ. of Queensland, Brisbane, QLD, Australia
Abstract :
In microarray data analysis, dimension reduction is an important consideration in the construction of a successful classification algorithm. As an alternative to feature selection, we use a well-known matrix factorisation method. For example, we can employ the popular singular-value decomposition (SVD) or nonnegative matrix factorization. In this paper, we consider a novel algorithm for gradient-based matrix factorisation (GMF). We compare GMF and SVD in their application to five gene expression datasets. The experimental results show that our method is faster, more stable, and sensitive.
Keywords :
bioinformatics; biological techniques; data reduction; gradient methods; matrix algebra; molecular biophysics; singular value decomposition; SVD; classification algorithm; dimension reduction; gene expression data classification; gene expression datasets; gradient based matrix factorisation; matrix factorization methods; microarray data analysis; nonnegative matrix factorization; singular value decomposition; Accuracy; Bioinformatics; Colon; Conferences; Gene expression; Matrix decomposition; Symmetric matrices;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-8306-8
Electronic_ISBN :
978-1-4244-8307-5
DOI :
10.1109/BIBM.2010.5706640