Title :
Optical reflectance spectroscopy for detection of human prostate cancer
Author :
Sharma, Vikrant ; Kashyap, Dheerendra ; Mathker, Aditya ; Narvenkar, Sweta ; Bensalah, Karim ; Kabbani, Wareef ; Tuncel, Altug ; Cadeddu, Jeffrey A. ; Liu, Hanli
Author_Institution :
Int. Techlink Group, Inc, Arlington, TX, USA
Abstract :
We present the method and application of optical reflectance spectroscopy to differentiate prostate cancer from normal tissue using a needle like, bifurcated, fiber-optic probe. An analytical expression to model light reflectance recently published by Zonios et. al. was used to derive optical properties of tissue. A total of 23 cases of human prostate specimens were investigated to analyze statistical differences between the respective cancerous tissues versus normal tissues. The results demonstrate that the derived hemodynamic parameters and optical properties can serve as good bio-markers to differentiate tumor tissue from normal tissue in human prostate.
Keywords :
bio-optics; biological organs; biomedical measurement; cancer; fibre optic sensors; haemodynamics; infrared spectroscopy; light reflection; statistical analysis; tumours; analytical expression; bio-markers; hemodynamic parameters; human prostate cancer detection; needle like bifurcated fiber-optic probe; normal tissue optical properties; optical reflectance spectroscopy; prostate cancer tissue differentiation; statistical differences; Algorithms; Diagnosis, Computer-Assisted; Humans; Male; Nephelometry and Turbidimetry; Oxygen; Prostatic Neoplasms; Spectrum Analysis; Tumor Markers, Biological;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5334830
