Title :
Cascade monitoring of temperature and dissolved oxygen in the growth of pichia pastoris in a bioreactor
Author :
Medina, J. ; Ruiz, F.
Author_Institution :
Dept. de Electron., Pontificia Univ. Javeriana, Bogotá, Colombia
Abstract :
It presents the modeling and control of oxygen dissolved in the growth phase of the Pichia Pastoris yeast in a bioreactor through the manipulation of the temperature in the growth environment. Four models of non-minimum phase are obtained from experimental data for different operation conditions and design a PI type controller, which is capable of stabilizing all models. The performance of the controller is verified through HIL (Hardware in the Loop) simulations in a real culture. The results obtained are satisfactory for the regulation of the dissolved oxygen in the growth phase of the culture.
Keywords :
PI control; bioreactors; control system synthesis; microorganisms; temperature control; PI type controller design; Pichia Pastoris yeast growth; bioreactor; dissolved oxygen monitoring; hardware-in-the-loop simulation; temperature monitoring; Bioreactor; PI control; experimental model; non-minimum phase systems;
Conference_Titel :
Robotics Symposium, 2011 IEEE IX Latin American and IEEE Colombian Conference on Automatic Control and Industry Applications (LARC)
Conference_Location :
Bogota
Print_ISBN :
978-1-4577-1689-8
DOI :
10.1109/LARC.2011.6086841
