Modeling studies of cellular response to ultrashort, high-intensity electric fields

Author

Joshi, R.P. ; Hu, Q. ; Schoenbach, K.H. ; Lakdawala, V.K.

Author_Institution

Dept. of Electr. & Comput. Eng., Old Dominion Univ., Norfolk, VA, USA

fYear

2003

fDate

19-22 Oct. 2003

Firstpage

357

Lastpage

360

Abstract

The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.

Keywords

bioelectric phenomena; biological effects of fields; cancer; cellular effects of radiation; radiation therapy; Smoluchowski equations; biological cells; cancer cells; cell membranes; cell responses; cell substructures; cellular response; current continuity; distributed current model; dynamic conductivities; electroporation; pore formation; potential distribution; tonsillar B-cells; ultrashort high-intensity electric fields; Biological cells; Biological system modeling; Biomembranes; Cancer; Cells (biology); Circuit simulation; Conductivity; Equations; Nanobioscience; Solid modeling;

fLanguage

English

Publisher

ieee

Conference_Titel

Electrical Insulation and Dielectric Phenomena, 2003. Annual Report. Conference on

Print_ISBN

0-7803-7910-1

Type

conf

DOI

10.1109/CEIDP.2003.1254867

Filename

1254867