Title :
Magnetic Fluid Hyperthermia Modeling Based on Phantom Measurements and Realistic Breast Model
Author :
Miaskowski, A. ; Sawicki, B.
Author_Institution :
Dept. of Appl. Math. & Comput. Sci., Univ. of Life Sci., Lublin, Poland
Abstract :
Magnetic fluid hyperthermia (MFH) is a minimally invasive procedure that destroys cancer cells. It is based on a superparamagnetic heat phenomenon and consists in feeding a ferrofluid into a tumor, and then applying an external electromagnetic field, which leads to apoptosis. The strength of the magnetic field, optimal dose of the ferrofluid, the volume of the tumor and the safety standards have to be taken into consideration when MFH treatment is planned. In this study, we have presented the novel complementary investigation based both on the experiments and numerical methodology connected with female breast cancer. We have conducted experiments on simplified female breast phantoms with numerical analysis and then we transferred the results on an anatomically-like breast model.
Keywords :
bioelectric potentials; biomagnetism; cancer; cellular biophysics; hyperthermia; iron compounds; magnetic fluids; magnetoelectric effects; numerical analysis; phantoms; tumours; Fe3O4; MFH treatment plan; anatomically-like breast model; apoptosis; cancer cell destruction; complementary investigation; external electromagnetic field; female breast cancer; female breast phantoms; ferrofluid; magnetic field strength; magnetic fluid hyperthermia modeling; minimally invasive procedure; numerical analysis; numerical methodology; optimal dose; phantom measurements; realistic breast model; superparamagnetic heat phenomenon; tumor; Equations; Heating; Mathematical model; Numerical models; Phantoms; Temperature measurement; Tumors; Bioelectromagnetics; Pennes equation; magnetic fluid hyperthermia (MFH); Biomimetics; Body Temperature; Breast Neoplasms; Computer Simulation; Equipment Design; Equipment Failure Analysis; Female; Humans; Hyperthermia, Induced; Magnetic Field Therapy; Models, Biological;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2013.2242071