On Modeling Insulin and Glucose Kinetics

The purpose of this study is to form an accurate estimation scheme to model the body´s response to insulin. In this experiment, a standard model is utilized because of its ability to predict the time course of glucose after glucose injection and the feasibility and precision of parameter estimation. An estimation scheme using extended filtering techniques will be implemented. The input to the estimator is the measured plasma glucose concentration and the estimators will return the plasma insulin concentration. The estimated insulin values will be compared to physiological data from a frequently sampled intravenous glucose tolerance test (FSIVGTT).