Title :
On Modeling Insulin and Glucose Kinetics
Author :
Dodson, Haley S. ; O´Brien, Richard T., Jr.
Author_Institution :
Dept. of Syst. Eng., United States Naval Acad., Annapolis, MD
Abstract :
The purpose of this study is to form an accurate estimation scheme to model the body´s response to insulin. In this experiment, a standard model is utilized because of its ability to predict the time course of glucose after glucose injection and the feasibility and precision of parameter estimation. An estimation scheme using extended filtering techniques will be implemented. The input to the estimator is the measured plasma glucose concentration and the estimators will return the plasma insulin concentration. The estimated insulin values will be compared to physiological data from a frequently sampled intravenous glucose tolerance test (FSIVGTT).
Keywords :
physiological models; proteins; reaction kinetics; sugar; body response; glucose injection; glucose kinetics; insulin kinetics; intravenous glucose tolerance test; parameter estimation; plasma glucose concentration; plasma insulin concentration; Degradation; Diabetes; Insulin; Kinetic theory; Parameter estimation; Plasma chemistry; Plasma measurements; Plasma transport processes; Predictive models; Sugar;
Conference_Titel :
System Theory, 2007. SSST '07. Thirty-Ninth Southeastern Symposium on
Conference_Location :
Macon, GA
Print_ISBN :
1-4244-1126-2
Electronic_ISBN :
0094-2898
DOI :
10.1109/SSST.2007.352370
