An in vitro system for modeling brain reactive responses and changes in neuroprosthetic device impedance

Author

Frampton, John P. ; Hynd, Mathew R. ; Vargun, Aytekin ; Roysam, Badri ; Shain, William

Author_Institution

Dept. of Biomed. Sci., State Univ. of New York at Albany, Albany, NY, USA

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

7155

Lastpage

7158

Abstract

Currently available methods for analyzing the structural properties of neural tissue are limited by the frequency at which data can be collected and by the need to sacrifice the specimen to correlate histology with other data. Electrical impedance spectroscopy (EIS) can be used to complement conventional histological and imaging-based methods by measuring real-time electrical data that can be ascribed to changes in tissue composition and structure. This report describes an impedance-based method for the analysis and modeling of the electrical properties of three-dimensional neural tissue constructs in vitro. This model system was used to assess the effects of cell density, type and organization on neuroprosthetic device electrode performance.

Keywords

bioelectric phenomena; biomedical electrodes; brain; cellular biophysics; electric impedance measurement; neurophysiology; prosthetics; 3D neural tissue construct electrical properties; brain reactive response modeling; cell density effects; cell organization effects; cell type effects; electrical impedance spectroscopy; impedance based method; in vitro system; neural tissue structural properties; neuroprosthetic device electrode performance; neuroprosthetic device impedance changes; Animals; Biomedical Engineering; Brain; Cells, Cultured; Electric Impedance; Electrodes, Implanted; Electrophysiological Phenomena; Microelectrodes; Models, Neurological; Prostheses and Implants; Spectrum Analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5335352

Filename

5335352