DocumentCode
2432624
Title
Theoretical and experimental study of electroporation of red blood cells using MEMS technology
Author
Deng, Peigang ; Yin, Guangyao ; Zhang, Tong-Yi ; Chang, Donald C. ; Lee, Yi-Kuen
Author_Institution
KAUST-HKUST Joint Micro/Nanofluidics Lab., Hong Kong Univ. of Sci. & Technol., Hong Kong, China
fYear
2010
fDate
20-23 Jan. 2010
Firstpage
595
Lastpage
598
Abstract
A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC´s membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions.
Keywords
bioelectric phenomena; biological effects of fields; biomembranes; blood; cellular biophysics; MEMS technology; RBC membrane; electroporation electric field strength; energy based model; microelectroporaion chip; red blood cell electroporation; strain energy; electroporation; micro electroporation chip; red blood cell; strain energy;
fLanguage
English
Publisher
ieee
Conference_Titel
Nano/Micro Engineered and Molecular Systems (NEMS), 2010 5th IEEE International Conference on
Conference_Location
Xiamen
Print_ISBN
978-1-4244-6543-9
Type
conf
DOI
10.1109/NEMS.2010.5592472
Filename
5592472
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