Title :
Single virus detection using integrated optofluidics
Author :
Rudenko, M.I. ; Kühn, S. ; Lunt, E.J. ; Deamer, D.W. ; Hawkins, A.R. ; Schmidt, H.
Author_Institution :
Sch. of Eng., Univ. of California, Santa Cruz, CA
Abstract :
Detection and analysis of single enterobacteria phage Qbeta nucleocapsids on an integrated optofluidic chip are presented. Diffusion coefficient and flow velocity of the capsids were measured to be 16.4plusmn0.5 mum2/s and 60-225 mum/s respectively.
Keywords :
biodiffusion; biosensors; fluidic devices; fluorescence; integrated optics; integrated optoelectronics; microorganisms; molecular biophysics; optical sensors; patient diagnosis; velocity measurement; ARROW biosensor; diffusion coefficient; flow velocity measurement; fluorescent detection; integrated optofluidic chip; integrated optofluidic sensor; single enterobacteria phage Qbeta nucleocapsid analysis; single virus detection; velocity 60 mum/s to 225 mum/s; Autocorrelation; Biosensors; Equations; Fluctuations; Fluorescence; Geometry; Optical waveguides; Particle tracking; Signal analysis; Spectroscopy;
Conference_Titel :
IEEE/LEOS Summer Topical Meetings, 2008 Digest of the
Conference_Location :
Acapulco
Print_ISBN :
978-1-4244-1925-8
Electronic_ISBN :
1099-4742
DOI :
10.1109/LEOSST.2008.4590548
