Title :
Determination of roxithromycin by spectrophotometry based on thymol blue charge transfer reaction
Author :
Li, Jun ; Liu, Ying ; Chang, Fang-Fang ; Wang, Guo-Qing ; Li, Quan-Min
Author_Institution :
Dept. of Chem. & Biol., Jiaozou Teachers Coll., Jiaozuo, China
Abstract :
An UV-Vis spectrophotometric method for determination of roxithromycin was developed based on the charge transfer reaction between roxithromycin as the donor and thymol blue as the acceptor in alcohol medium. The experimental results showed that roxithromycin reacted with thymol blue to form an 1:1 complex at room temperature, the apparent molar absorptivity of the complex was 1.70×103 L·mol-1·cm-1 at 438nm, the stability constant was 1.53×106, and the linear range of the determination was 41.9~419 mg·L-1.
Keywords :
charge exchange; drugs; spectrochemical analysis; ultraviolet spectra; visible spectra; UV-Vis spectrophotometry; molar absorptivity; roxithromycin; stability constant; temperature 293 K to 298 K; thymol blue charge transfer reaction; wavelength 438 nm; Decision support systems; Charge transfer reaction; Roxithromycin; Spectrophotometry; Thymol blue;
Conference_Titel :
Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-9172-8
DOI :
10.1109/RSETE.2011.5964058
