Title :
Applying evolutionary computation to understanding the insertion behavior of LINE-1 retrotransposons in human DNA
Author :
Meade, Andrew ; Corne, David ; Sibly, Richard
Author_Institution :
Sch. of Comput. Sci., Reading Univ., UK
Abstract :
Mobile genetic elements, portions of DNA which are able to copy themselves elsewhere into the genome, have played a substantial role during evolution. One of the most prominent such elements is the LINE-1 retrotransposon, a section of DNA around 6,000 nucleotide bases in length, which is thought to account for about 15% of the current state of the human genome. The mechanism of LINE-1 insertion is rather poorly understood. However, achieving a good understanding of this process is fundamental to understanding natural evolution at the molecular level. We describe a first approach to use evolutionary computation to explore models for the LINE-1 insertion process. A range of findings from standard genome studies are able to suggest the basic parameters and structure of an insertion model. We use an evolutionary algorithm to explore a space of such models
Keywords :
DNA; biology computing; evolutionary computation; genetics; DNA; LINE-1 retrotransposons; evolution; evolutionary algorithm; evolutionary computation; genome; insertion model; mobile genetic elements; nucleotide bases; Bioinformatics; Computer science; DNA; Evolutionary computation; Genetics; Genomics; Humans; Proteins; RNA; Space exploration;
Conference_Titel :
Evolutionary Computation, 2000. Proceedings of the 2000 Congress on
Conference_Location :
La Jolla, CA
Print_ISBN :
0-7803-6375-2
DOI :
10.1109/CEC.2000.870717