Title :
Multiscale 3D model of cardiac contraction based on a fiber array
Author :
Amar, A. ; Witman, S. ; Barnea, O.
Author_Institution :
Dept. of Biomed. Eng., Tel Aviv Univ., Ramat Aviv, Israel
Abstract :
The heart has been modeled as an anatomically arranged and oriented array of contracting fibers. The model was developed to study the interplay between cellular mechanisms and global myocardial function. Our modeling approach combines cellular electrophysiology, force development, and anatomical ventricle model into a multiscale model of cardiac contraction. The model represents myocardial deformation and fluid dynamics. Results show that the multiscale ventricular model is capable of simulating mechanical contraction, pressure generation and load interactions.
Keywords :
bioelectric phenomena; biomechanics; cardiology; cellular biophysics; muscle; physiological models; anatomical ventricle model; anatomically arranged contracting fiber array; anatomically oriented contracting fiber array; cardiac contraction multiscale model; cellular electrophysiology; cellular mechanisms; fiber array based cardiac contraction multiscale 3D model; fluid dynamics; force development; global myocardial function; load interactions; mechanical contraction; myocardial deformation; pressure generation; Biological system modeling; Calcium; Force; Heart; Mathematical model; Myocardium; Solid modeling; Mathematical model; cardiac contraction; cardiac electrophysiology;
Conference_Titel :
Electrical & Electronics Engineers in Israel (IEEEI), 2012 IEEE 27th Convention of
Conference_Location :
Eilat
Print_ISBN :
978-1-4673-4682-5
DOI :
10.1109/EEEI.2012.6377090
